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NEUROLOGY 1985;35:1544
© 1985 American Academy of Neurology

Clinical subtypes of dementia of the Alzheimer type

Helena Chang Chui, MD, Evelyn Lee Teng, PhD, Victor W. Henderson, MD and Arthur C. Moy, MA

From the Department of Neurology (Drs. Chui, Teng, Henderson, and May), University of Southern California School of Medicine, Los Angeles; and the Department of Neurology (Drs. Chui and Henderson), Rancho Los Amigos Medical Center, Downey, CA.

Clinical subtypes of dementia of the Alzheimer type were evaluated by comparing age at onset, aphasia, family history, and motor disorder in 146 individuals with progressive dementia. Early onset was significantly associated with more prevalent and more severe language disorder. Forty-five percent of all probands had familial history of dementia, but we could not differentiate relative familial risk based on age at onset or aphasia. Independent of duration of illness, myoclonus and noniatrogenic extrapyramidal disorder were associated with greater severity of dementia.

Address correspondence and reprint requests to Dr. Chui, Rancho Los Amigos Medical Center, 12824 Erickson Street, Downey, CA 90242.

Supported by an NIH-Teacher Investigator Award (1K07-N500-794-01), the USC Faculty Research and Innovation Fund, and the Mather Foundation.

Accepted for publication March 7, 1985.




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