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Effect of simultaneously ingested milk on phenytoin bioavailability

From the Francis M. Forster Epilepsy Center, William S. Middleton Memorial Veterans Hospital, and the Department of Neurology, University of Wisconsin Hospitals and Clinics, Madison, WI. Dr. Kang's present address: Pediatric Neurology, Albany Medical College, 47 New Scotland Ave., Albany, NY 12208.

Adverse gastrointestinal symptoms from milk may reduce the bioavailability of phenytoin. In a prospective crossover study, wg studied the effect of simultaneous ingestion of phenytoin and milk in 12 patients with partial epilepsy and no adverse gastrointestinal symptoms. Serum phenytoin levels were measured at the start of the study and after 2 weeks. Patients then switched regimens, and a third phenytoin level was determined 2 weeks later. Seruy phenytoin levels were similar for patients taking phenytoin with either milk or water.

Address correspondence and reprint requests to Dr. Dasheiff, Department of Neurology, 322 Scaife Hall, University of Pittsburgh, Pittsburgh, PA 15261.

Supported in part by the Veterans Administration. Phenytoin was purchased from Parke-Davis.

Accepted for publication January 28, 1985.