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Creutzfeldt-Jakob disease

Possible medical risk factors

From the Neuroepidemiology Section. Department of Neurology, Temple University. School of Medicine (Drs. Davanipour, Alter, and Sobel), Philadelphia, PA: and the Laboratory of Central Nervous System Studies. NINCDS, National Institutes of Health (Drs. Asher and Gajdusek), Bethesda, MD.

To explore possible risk factors in the past medical history of patients with Creutzfeldt-Jakob disease (CJD), we conducted a case-control study among 26 cases and 40 matched controls. Statistically significant odds ratios were obtained for intraocular pressure testing; injury to or surgery on the head, face, or neck; and trauma to other parts of the body. The odds ratios were nearly significant for head trauma and procedures requiring sutures. These data suggest that the CJD agent may be acquired by inoculation through injury or during surgery, and perhaps on certain absorbable sutures of animal origin. The tonometer used for glaucoma testing may also be a vehicle of transmission.

Address correspondence and reprint requests to Dr. Davanipour, Department of Neurology, Temple University, School of Medicine, Philadelphia, PA 19140.

Presented in part at the thirty-seventh annual meeting of the American Academv of Neurology, Dallas, TX. April 1985.

Accepted for publication January 24, 1985.

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