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NEUROLOGY 1985;35:1470
© 1985 American Academy of Neurology

Chronic encephalitis possibly due to herpes simplex virus

Two cases Jacob I. Sage, MD, Melvin P. Weinstein, MD and Douglas C. Miller, MD, PhD

From the Departments of Neurology (Dr. Sage), Medicine (Dr. Weinstein), and Pathology (Drs. Weinstein and Miller), UMDNJ-Rutgers Medical School. Academic Health Science Center, New Brunswick, NJ.

Two patients had clinical findings of encephalopathy that progressed in 4 to 5 months. One patient had headache, fatigue, lethargy, hemi-paresis, and a seizure. The second patient had only forgetfulness, confusion, and lethargy without focal signs. Herpes simplex virus was grown from brain biopsy in the first patient and from CSF in the second patient. These cases suggest that herpes simplex virus caused the encephalitis and that it should be considered in the differential diagnosis of chronic encephalopathy.

Address correspondence and reprint rcquests to Dr. Sage, Department of Neurology, UMDNJ-Rutgers Medical School. Academic Health Science Center, CN 19, New Brunswick, NJ 08903.

Accepted for publication January 16, 1985.




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