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Prevention of experimental allergic encephalomyelitis by anterior hypothalamic lesion in rats

From the Department or Neurology. Hadassah University Hospital ant1 Hebrew University—Hadassah Medical School, Jerusalem, Israel.

Bilateral electrical lesions were performed in the anterior hypothalamus (AH) and hippocampus (HC) of female Lewis rats. AH but not HC lesions were found to inhibit the appearance of clinical signs typical of experimental allergic encephalomyelitis (EAE). The incidence of EAE was 17.2% and the duration was 1.33 ± 0.07 days after AH lesions compared with an incidence of 85% and duration of 4.81 ± 0.6 days in the controls. Destruction of the AH was followed by decreased levels of antibodies to myelin basic protein and increased reactivity of splenic lymphocytes to concanavalin A, but did not affect the extent of mono-nuclear cell infiltration within the brain and spinal cord.

Address correspondence and reprint requests to Dr. Wertman, Department of Neurology. Hadassah University Hospital. P.O.B. 12000, Jerusalem, 91 120, Israel.

Supported in part by the Israeli Multiple Sclerosis Society

Accepted for publication January 15, 1985.