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NEUROLOGY 1985;35:1466
© 1985 American Academy of Neurology

Sensory neuropathy with low-dose pyridoxine

Gareth J. Parry, MB, FRACP and Dale E. Bredesen, MD

From the Department of Neurology, University of California School of Medicine, San Francisco, CA.

We describe 16 patients with neuropathy associated with pyridoxine abuse. The clinical picture of a pure sensory central-peripheral distal axonopathy was consistent. Pyridoxine dose was 0.2 to 5 g/d, and duration of consumption before symptoms was inversely proportional to the daily intake. In all patients with adequate follow-up, improvement followed discontinuation of pyridoxine. The ready availability of up to 1-gram tablets makes it likely that this neuropathy will continue to be seen.

Address correspondence and reprint requests to Dr. Parry, UCSF, Department of Neurology. M-794, San Francisco, CA 94143.

Accepted for publication January 15, 1985.

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