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From the Department of Neurology, University of California School of Medicine, San Francisco, CA.
We describe 16 patients with neuropathy associated with pyridoxine abuse. The clinical picture of a pure sensory central-peripheral distal axonopathy was consistent. Pyridoxine dose was 0.2 to 5 g/d, and duration of consumption before symptoms was inversely proportional to the daily intake. In all patients with adequate follow-up, improvement followed discontinuation of pyridoxine. The ready availability of up to 1-gram tablets makes it likely that this neuropathy will continue to be seen.
Address correspondence and reprint requests to Dr. Parry, UCSF, Department of Neurology. M-794, San Francisco, CA 94143.
Accepted for publication January 15, 1985.
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