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NEUROLOGY 1985;35:1450
© 1985 American Academy of Neurology

The gait abnormality of Huntington's disease

William C. Koller, MD, PhD and John Trimble, PhD

From the Neurology Department (Dr. Koller), Loyola University School of Medicine, and Hines VA Hospital, Chicago; and the Rehabilitation Research and Development Department (Dr. Trimble), Hines VA Hospital, Hines, IL.

We investigated 13 patients with Huntington's disease and assessed gait by filming and by gait analyzer before and after increasing haloperidol dosage, until chorea was suppressed or side effects intervened. The severity of chorea and ataxia was scored blindly from videotapes. Gaits were abnormal in 12 of 13 patients and 5 of 6 patients who had symptoms for less than 5 years. Clinical characteristics included wide-based station, lateral swaying, spontaneous knee flexion, variable cadence, and parkinsonian features. Biomechanical analysis illustrated that gait characteristics varied in each walk, with a mean decrease in velocity, stride length, and cadence. Haloperidol treatment decreased chorea but did not affect gait patterns. Ataxia occurs early in the disease, has a distinct but variable pattern, is unrelated to chorea, and is not improved by haloperidol.

Address correspondence and reprint requests to Dr. Koller. Neurology Service, Hines VA Hospital. Hines, IL 60141.

Supported in part by funds from the Veterans Administration Rehabilitation Research and Development Service.

Accepted for publication January 14, 1985.




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