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Multiple sclerosis

Free light chains in cerebrospinal fluid

From the Departments of Neurology (Dr. Rudick) and Medicine (Dr. Knutson), and the Center for Brain Research (Drs. Rudick and Bidlack), The University of Rochester School of Medicine and Dentistry, Rochester, NY.

We found free light chains in the CSF of 18 MS patients, but not in any of 14 patients with other neurologic disease. CSF from all MS patients contained kappa and lambda chain dimers, less frequently contained light chain monomers, and never contained free gamma heavy chains. Light chains were not detected in matched serum samples. CSF from MS patients did not release free light chains from whole IgG in CSF of controls. The findings suggest that these free light chains originate in plasma cells, not from degradation of whole IgG.

Address corresprrndence and reprint requests to Dr. Rudick, Box 605, Strong Memorial Hospital, Rochester. NY 14642.

This work was supported in part by a Biomedical Research Support Grant to Dr. Rudick from the University of Rochester School of Medicine and by PHS Grant RO1 NS20303. Dr. Rudick is the recipient of NINCDS Teacher Investigator Development Award K07 NS00791. Mr. Peter was the recipient of a Medical Student Fellowship from the University of Rochester School of Medicine supported by NIH Training Grant 5 P35 HL-07496.

Accepted for publication January 10, 1985.

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