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NEUROLOGY 1985;35:1438
© 1985 American Academy of Neurology

Optic nerve demyelination induced by human serum

Patients with multiple sclerosis or optic neuritis and normal subjects

Robert C. Sergott, MD, Mark J. Brown, MD, Roseann M-D. Polenta, BS, Robert P. Lisak, MD and Donald H. Silberberg, MD

From the Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, PA.

We injected guinea pig optic nerves with serum from patients with MS or acute optic neuritis (ON), or normal subjects. Serum from 12 of 17 MS patients, 3 of 3 patients with ON, and 5 of 11 normal age- and sex-matched controls produced myelin vesiculation and demyelination 24 hours after injection. Nerves injected with demyelinating serum contained oligodendrocytes with pyknotic nuclei and edematous, rarefied cytoplasm. Nerves injected with serum that did not cause demyelination did not have these oligodendrocyte changes. Serum from normal subjects or patients with MS may induce in vivo demyelination in mammalian CNS.

Address correspondence and reprint requests to Dr. Sergott, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104.

Supported by USPHS Grants No. NS11037 and NS08075 and the Multiple Sclerosis Society.

Accepted for publication January 28, 1985.




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