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From the Departments of Neurology Anatomy, and Pathology, Lexington VA and University of Kentucky Medical Centers, and Sanders Brown Research Center on Aging, University of Kentucky, Lexington, KY.
Cholinergic enzyme activity (choline acetyltransferase, CAT acetylcholinesterase, AChE) and muscarinic cholinergic receptor density were measured in frontal cortex (Brodmann's area 9) of normal patients over the life span and in brains of patients with Alzbeimer's disease (AD). CAT, but not AChE activity, declined with normal aging. Significant loss of CAT and AChE activity occurred in the AD brains, but later onset AD was associated with less severe loss of frontal cortex CAT activity. The majority of normal CAT activity resided in lamina I, II, and upper lamina III; CAT loss in AD resulted in large losses from all depths, most notably the upper cortical layers. AChE did not precisely correspond to the localization of CAT; loss of AChE in AD was consistent across all six laminae. No differences were seen in muscarinic cholinergic receptor binding between AD and age-matched controls; the distribution of binding was equal in all layers of normal frontal cortex, and no laminar differences were detected in distribution of cholinergic receptors between normal and AD samples.
Address correspondence and reprint requests to Dr. S.T. DeKosky, Department of Neurology (127). VA Medical Center, Lexington. KY 40507
This research was supported by the Veterans Administration Research Service. Dr. DeKosky is a recipient of a Teacher Investigator Development Award (NS00444) from the NINCDS.
Accepted for publication January 10, 1985.
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