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Alterations of regional cerebral blood flow and oxygen metabolism in Parkinson's disease

From the Department of Neurology (Drs. Walfson and Brown), Albert Einstein College of Medicine, Bronx, NY; and the MRC Cyclotron Unit (Drs. Leenders and Jones), Hammersmith Hospital, London, England.

Regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO,) were determined in six normals, six unilateral Parkinson's disease (PD) patients, and eight bilateral PD patients. In the unilateral patients, rCBF and rCMRO₂ in the basal ganglia contralateral to the symptomatic limbs was 13% higher than on the other side (p < 0.01); in the frontal cortex it was 8% lower than the other side, suggesting abnormal neuronal function in both regions. The bilateral PD patients had a widespread decrease (20%) in rCBF unaccompanied by comparable changes in rCMRO₂, suggesting vasoconstriction due to loss of dopaminergic innervation of blood vessels in more advanced PD patients.

Address correspondence and reprint requests to Dr. Wolfson, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue. Bldg. F. Rm. 104S. Bronx, NY 10461.

Dr. Wolfson was supported in part by a Senior International Fogerty Fellowship as well as by an NIH research grant (NS 09649).

Accepted for publication December 11, 1984.

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