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Defective [U-14 C] Palmitic acid oxidation in Duchenne muscular dystrophy

Departments of Pediatrics (Dr. Carroll) and Neurology and Neurosurgery (Drs. Carroll and Brooke, and Miss Norris) (Neurology), Washington University School of Medicine, St. Louis, MO.

Compared with normal skeletal muscle, muscle from patients with Duchenne dystrophy had decreased [U-14 C] palmitic acid oxidation. [l-14 C] palmitic acid oxidation was normal. These results may indicate a defect in intramitochondrial fatty acid oxidation.

Address correspondence and reprint requests to Dr. Carroll, Director Pediatric Neurology, CK297, Medical College of Georgia, Augusta, GA 30912.

Supported by a Center Grant from the Muscular Dystrophy Association and by NIH Teacher Investigator Award (KO7-NS00386 to Dr. Carroll.

Accepted for publication April 6, 1984.

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