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NEUROLOGY 1985;35:42
© 1985 American Academy of Neurology

Cerebral dysfunction after chronic hypoxia in children

Margaret O'Dougherty, PhD, Francis S. Wright, MD, Ruth B. Loewenson, PhD and Fernando Torres, MD

Department of Pediatrics, The Ohio State University and the Children's Hospital (Drs. O'Dougherty and Wright), Columbus. OH; and the Department of Neurology, University of Minnesota (Drs. Loewenson and Torres), Minneapolis.

Although the long-term effects of acute anoxia have been studied, the effects of chronic hypoxia on the developing human brain have received little attention. We studied children with a cyanotic congenital heart defect to assess the impact of chronic hypoxia by eight measures: neurologic examination, visual evoked response, EEG, behavioral adjustment, cognitive, perceptual-motor, and attentional functioning, and school performance. On outcome evaluation, these children evidenced diverse neurophysiologic dysfunction. Chronic hypoxia was associated with impaired motor function, inability to sustain attention, and low academic achievement.

Address correspondence and reprint requests to Dr. O'Dougherty, Department of Pediatrics, Children's Hospital, 700 Children's Drive, Columbus, OH 43205.

Supported by the William T. Grant Foundation, the Minnesota Medical Foundation (Grant SMF-262-79). and the Columbus Children's Hospital Research Foundation (Grant 74–322).

Accepted for publication April 15, 1984.




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