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Sleep Disorders Center, Hôpital du Sacré-Coeur (Drs. Montplaisir and DeChamplain, MM. Godbout and Lapierre), the Department of Medicine, Section of Neurology, Hôtel-Dieu Hospital (Dr. Boghen), and the Department of Psychiatry, McGill University (Dr. Young), Montreal.
Restless legs syndrome was present in nine members of a family over a span of five generations. In three subjects, the diagnosis was confirmed by all-night sleep recordings and concomitant EMG. Two of these three subjects also had periodic movements in sleep. The frequency of leg movements decreased from wakefulness to stages 1 and 2 non-REM sleep. There was an increase of free dopamine and homovanillic acid in CSF of the propositus. Clonazepam effectively controlled restless legs in the propositus and his mother.
Address correspondence and reprint requests to Dr. Montplaisir, Centre d'étude du sommeil, Hôpital du Sacré-Coeur, 5400 Boulevard Gouin Ouest, Montréal, Québec H4J 1C5, Canada.
Supported by grants from the Medical Research Council of Canada.
Accepted for publication April 24, 1984.
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