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NEUROLOGY 1984;34:966
© 1984 American Academy of Neurology

Decreased 6-hydroxymelatonin excretion in Korsakoff's psychosis

Peter R. Martin, MD, FRCP(C), Sadayoshi Higa, MD, PhD, R. Stanley Burns, MD, Lawrence Tamarkin, PhD, Michael H. Ebert, MD and Sanford P. Markey, PhD

From the Laboratory of Clinical Studies (Dr. Martin). National Instituteon Alcohol Abuse and Alcoholism: the Laboratory of Clinical Science (Drs. Martin, Higa, Burns, Ebert, and Markey). National Institute of Mental Health; and National Institute of Child Health and Human Development (Dr. Tamarkin), National Institutes of Health. Bethesda, MD.

Mean (± SEM) urinary excretion rate of the major melatonin metabolite 6-hydroxymelatonin (µg/day) was lower in 7 (2.8 + 1.0) of 8 men with Korsakoffs psychosis (KP) than in 15 healthy men (11.4 ± 1.4). Treatment with the {alpha}2-noradrenergic agonist clonidine decreased daily 6-hydroxymelatonin excretion (p < 0.02). Reduced daily excretion of 6-hydroxymelatonin in KP reflects decreased melatonin synthesis in the pineal gland, perhaps as a residual effect of lesions due to past thiamine deficiency (Wernicke's encephalopathy).

Address correspondence and reprint requests to Dr. Martin, National Institutes of Health. Building 10, Room: 38-19, 9000 Rockville Pike, Bethesda, MD 20205.

Accepted for publication November 4, 1983.




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