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Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Address correspondence and reprint requests to Dr. Stadlan, 7550 Wisconsin Avenue, Federal Building, Room 700, Bethesda, MD 20205.
*For Work Group Participants and Affiliations, see page 943.
Accepted for publication March 20, 1984.
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M. Zarei, J. S. Damoiseaux, C. Morgese, C. F. Beckmann, S. M. Smith, P. M. Matthews, P. Scheltens, S. A.R.B. Rombouts, and F. Barkhof Regional White Matter Integrity Differentiates Between Vascular Dementia and Alzheimer Disease Stroke, March 1, 2009; 40(3): 773 - 779. [Abstract] [Full Text] [PDF] |
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W. Dai, O. L. Lopez, O. T. Carmichael, J. T. Becker, L. H. Kuller, and H. M. Gach Mild Cognitive Impairment and Alzheimer Disease: Patterns of Altered Cerebral Blood Flow at MR Imaging Radiology, March 1, 2009; 250(3): 856 - 866. [Abstract] [Full Text] [PDF] |
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O. Piguet, M. Hornberger, B. P. Shelley, C. M. Kipps, and J. R. Hodges Sensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia Neurology, February 24, 2009; 72(8): 732 - 737. [Abstract] [Full Text] [PDF] |
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B. Kuczynski, W. Jagust, H. C. Chui, and B. Reed An inverse association of cardiovascular risk and frontal lobe glucose metabolism Neurology, February 24, 2009; 72(8): 738 - 743. [Abstract] [Full Text] [PDF] |
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K. Hu, E. J. W. Van Someren, S. A. Shea, and F. A. J. L. Scheer Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker PNAS, February 24, 2009; 106(8): 2490 - 2494. [Abstract] [Full Text] [PDF] |
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V. Rondeau, H. Jacqmin-Gadda, D. Commenges, C. Helmer, and J.-F. Dartigues Aluminum and Silica in Drinking Water and the Risk of Alzheimer's Disease or Cognitive Decline: Findings From 15-Year Follow-up of the PAQUID Cohort Am. J. Epidemiol., February 15, 2009; 169(4): 489 - 496. [Abstract] [Full Text] [PDF] |
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R. L. Buckner, J. Sepulcre, T. Talukdar, F. M. Krienen, H. Liu, T. Hedden, J. R. Andrews-Hanna, R. A. Sperling, and K. A. Johnson Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease J. Neurosci., February 11, 2009; 29(6): 1860 - 1873. [Abstract] [Full Text] [PDF] |
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J. D. Dawson, S. W. Anderson, E. Y. Uc, E. Dastrup, and M. Rizzo Predictors of driving safety in early Alzheimer disease Neurology, February 10, 2009; 72(6): 521 - 527. [Abstract] [Full Text] [PDF] |
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S. Reeves, R. Brown, R. Howard, and P. Grasby Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease Neurology, February 10, 2009; 72(6): 528 - 534. [Abstract] [Full Text] [PDF] |
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F. Agosta, K. A. Vossel, B. L. Miller, R. Migliaccio, S. J. Bonasera, M. Filippi, A. L. Boxer, A. Karydas, K. L. Possin, and M. L. Gorno-Tempini Apolipoprotein E {varepsilon}4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia PNAS, February 10, 2009; 106(6): 2018 - 2022. [Abstract] [Full Text] [PDF] |
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L. Mosconi, R. Mistur, R. Switalski, M. Brys, L. Glodzik, K. Rich, E. Pirraglia, W. Tsui, S. De Santi, and M. J. de Leon Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease Neurology, February 10, 2009; 72(6): 513 - 520. [Abstract] [Full Text] [PDF] |
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