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NEUROLOGY 1984;34:939
© 1984 American Academy of Neurology

Clinical diagnosis of Alzheimer's disease

Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

Guy McKhann, MD, David Drachman, MD, Marshall Folstein, MD, Robert Katzman, MD, Donald Price, MD and Emanuel M. Stadlan, MD

Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.

Address correspondence and reprint requests to Dr. Stadlan, 7550 Wisconsin Avenue, Federal Building, Room 700, Bethesda, MD 20205.

*For Work Group Participants and Affiliations, see page 943.

Accepted for publication March 20, 1984.




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J Geriatr Psychiatry NeurolHome page
J. Razani, J. T. Wong, N. Dafaeeboini, T. Edwards-Lee, Po Lu, C. Alessi, and K. Josephson
Predicting Everyday Functional Abilities of Dementia Patients With the Mini-Mental State Examination
J Geriatr Psychiatry Neurol, March 1, 2009; 22(1): 62 - 70.
[Abstract] [PDF]


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J Geriatr Psychiatry NeurolHome page
D. C. Steffens, D. R. McQuoid, and G. G. Potter
Outcomes of Older Cognitively Impaired Individuals With Current and Past Depression in the NCODE Study
J Geriatr Psychiatry Neurol, March 1, 2009; 22(1): 52 - 61.
[Abstract] [PDF]


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Am. J. Neuroradiol.Home page
R.S. Desikan, H.J. Cabral, B. Fischl, C.R.G. Guttmann, D. Blacker, B.T. Hyman, M.S. Albert, and R.J. Killiany
Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease
AJNR Am. J. Neuroradiol., March 1, 2009; 30(3): 532 - 538.
[Abstract] [Full Text] [PDF]


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Arch NeurolHome page
K. Yaffe, A. L. Weston, T. Blackwell, and K. A. Krueger
The Metabolic Syndrome and Development of Cognitive Impairment Among Older Women
Arch Neurol, March 1, 2009; 66(3): 324 - 328.
[Abstract] [Full Text] [PDF]


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Arch NeurolHome page
A. L. Fitzpatrick, L. H. Kuller, O. L. Lopez, P. Diehr, E. S. O'Meara, W. T. Longstreth Jr, and J. A. Luchsinger
Midlife and Late-Life Obesity and the Risk of Dementia: Cardiovascular Health Study
Arch Neurol, March 1, 2009; 66(3): 336 - 342.
[Abstract] [Full Text] [PDF]


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Arch NeurolHome page
E. P. Helzner, J. A. Luchsinger, N. Scarmeas, S. Cosentino, A. M. Brickman, M. M. Glymour, and Y. Stern
Contribution of Vascular Risk Factors to the Progression in Alzheimer Disease
Arch Neurol, March 1, 2009; 66(3): 343 - 348.
[Abstract] [Full Text] [PDF]


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Arch NeurolHome page
S. Brar, D. Henderson, J. Schenck, and E. A. Zimmerman
Iron Accumulation in the Substantia Nigra of Patients With Alzheimer Disease and Parkinsonism
Arch Neurol, March 1, 2009; 66(3): 371 - 374.
[Abstract] [Full Text] [PDF]


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Arch NeurolHome page
T. Tapiola, I. Alafuzoff, S.-K. Herukka, L. Parkkinen, P. Hartikainen, H. Soininen, and T. Pirttila
Cerebrospinal Fluid {beta}-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain
Arch Neurol, March 1, 2009; 66(3): 382 - 389.
[Abstract] [Full Text] [PDF]


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Cereb CortexHome page
B. C. Dickerson, A. Bakkour, D. H. Salat, E. Feczko, J. Pacheco, D. N. Greve, F. Grodstein, C. I. Wright, D. Blacker, H. D. Rosas, et al.
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals
Cereb Cortex, March 1, 2009; 19(3): 497 - 510.
[Abstract] [Full Text] [PDF]


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BrainHome page
N. Finch, M. Baker, R. Crook, K. Swanson, K. Kuntz, R. Surtees, G. Bisceglio, A. Rovelet-Lecrux, B. Boeve, R. C. Petersen, et al.
Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
Brain, March 1, 2009; 132(3): 583 - 591.
[Abstract] [Full Text] [PDF]


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StrokeHome page
M. Zarei, J. S. Damoiseaux, C. Morgese, C. F. Beckmann, S. M. Smith, P. M. Matthews, P. Scheltens, S. A.R.B. Rombouts, and F. Barkhof
Regional White Matter Integrity Differentiates Between Vascular Dementia and Alzheimer Disease
Stroke, March 1, 2009; 40(3): 773 - 779.
[Abstract] [Full Text] [PDF]


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RadiologyHome page
W. Dai, O. L. Lopez, O. T. Carmichael, J. T. Becker, L. H. Kuller, and H. M. Gach
Mild Cognitive Impairment and Alzheimer Disease: Patterns of Altered Cerebral Blood Flow at MR Imaging
Radiology, March 1, 2009; 250(3): 856 - 866.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
O. Piguet, M. Hornberger, B. P. Shelley, C. M. Kipps, and J. R. Hodges
Sensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia
Neurology, February 24, 2009; 72(8): 732 - 737.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
B. Kuczynski, W. Jagust, H. C. Chui, and B. Reed
An inverse association of cardiovascular risk and frontal lobe glucose metabolism
Neurology, February 24, 2009; 72(8): 738 - 743.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
K. Hu, E. J. W. Van Someren, S. A. Shea, and F. A. J. L. Scheer
Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker
PNAS, February 24, 2009; 106(8): 2490 - 2494.
[Abstract] [Full Text] [PDF]


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Am J EpidemiolHome page
V. Rondeau, H. Jacqmin-Gadda, D. Commenges, C. Helmer, and J.-F. Dartigues
Aluminum and Silica in Drinking Water and the Risk of Alzheimer's Disease or Cognitive Decline: Findings From 15-Year Follow-up of the PAQUID Cohort
Am. J. Epidemiol., February 15, 2009; 169(4): 489 - 496.
[Abstract] [Full Text] [PDF]


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J. Neurosci.Home page
R. L. Buckner, J. Sepulcre, T. Talukdar, F. M. Krienen, H. Liu, T. Hedden, J. R. Andrews-Hanna, R. A. Sperling, and K. A. Johnson
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
J. Neurosci., February 11, 2009; 29(6): 1860 - 1873.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
J. D. Dawson, S. W. Anderson, E. Y. Uc, E. Dastrup, and M. Rizzo
Predictors of driving safety in early Alzheimer disease
Neurology, February 10, 2009; 72(6): 521 - 527.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
S. Reeves, R. Brown, R. Howard, and P. Grasby
Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease
Neurology, February 10, 2009; 72(6): 528 - 534.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
F. Agosta, K. A. Vossel, B. L. Miller, R. Migliaccio, S. J. Bonasera, M. Filippi, A. L. Boxer, A. Karydas, K. L. Possin, and M. L. Gorno-Tempini
Apolipoprotein E {varepsilon}4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia
PNAS, February 10, 2009; 106(6): 2018 - 2022.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
L. Mosconi, R. Mistur, R. Switalski, M. Brys, L. Glodzik, K. Rich, E. Pirraglia, W. Tsui, S. De Santi, and M. J. de Leon
Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease
Neurology, February 10, 2009; 72(6): 513 - 520.
[Abstract] [Full Text] [PDF]




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