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NEUROLOGY 1984;34:909
© 1984 American Academy of Neurology

Down's syndrome

Is there a decreased population of neurons?

Majorie H. Ross, Albert M. Galaburda and Thomas L. Kemper

From the Neurological Unit, Beth Israel Hospital and Department of Neurology, Harvard Medical School (Drs. Ross, Galaburda, and Kemper), and the Department of Neurology, Boston City Hospital, and Departments of Neurology and Anatomy, Boston University School of Medicine (Dr. Kemper). Boston, MA.

Although gross abnormalities have been described in the brains of patients with Down's syndrome (DS), microscopic studies have revealed only minor and inconsistent findings. We compared two DS brains, in whole-brain serial sections, with similarly prepared age- and sex-matched normal controls. Architectonic abnormalities were noted, and cell counts revealed a significant poverty of granular cells in the DS brains, particularly in granular fields such as areas 3,17, and 41. Golgi studies demonstrated all major cell types. A striking feature of the brain morphology in DS may be the curtailment of a specific cell type, most likely the aspinous stellate.

Address correspondence and reprint requests to Dr. Galaburda, Beth Israel Hospital, 330 Brookline Avenue, K420, Boston, MA 02215.

Supported in part by NIH grants NINCDS 14018 and 07211, as well as grants from the Beth Israel Hospital, the William Underwood Company, the Powder River Company, the Essel Foundation, and the Orton Dyslexia Society.

Accepted for publication November 23, 1983.




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