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NEUROLOGY 1984;34:898
© 1984 American Academy of Neurology

Physiologic analysis of the myoclonus of Alzheimer's disease

D. E. Wilkins, M. Hallett, A. Berardelli, T. Walshe and N. Alvarez

From the Section of Neurology, Department of Medicine (Drs. Wilkins, Hallett, and Berardelli), Brigham and Women's Hospital, Boston; Department of Neurology (Dr. Walshe), Brockton VA Medical Center, Brockton; Seizure Control Program of Wrentham State Hospital (Dr. Alvarez), Wrentham; and Department of Neurology (Drs. Wilkins, Hallett, Berardelli, Walshe, and Alvarez), Harvard Medical School, Boston, MA.

Ten patients with clinically diagnosed Alzheimer's disease, including three cases of trisomy 21(Down's syndrome), developed a chronic myoclonic disorder. The technique of jerk-locked averaging of EEG activity wasused to analyze the myoclonus. Seven subjects demonstrated a focal, contralateral central, negative cerebral potential antecedent to the myoclonic jerks. This EEG event differs from that previously reported to be associated with the myoclonus of subacute spongiform encephalopathy (Creutzfeldt-Jakob disease).

Address correspondence and reprint requests to Dr. Hallett, Clinical Director, NINCDS; NIH, Bldg. 10, Rm. 5N3226 Bethesda, MD 20205.

Presented in part at the American Academy of Neurology meeting in Washington, DC, April 1982.

Accepted for publication November 10, 1983.




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