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NEUROLOGY 1984;34:855
© 1984 American Academy of Neurology

Cerebral blood flow changes in benign aging and cerebrovascular disease

Terry G. Shaw, PhD, Karl F. Mortel, PhD, John Stirling Meyer, MD, Robert L. Rogers, MS, Jeffery Hardenberg, BS and Michael M. Cutaia, MA

From the Cerebral Blood Flow Laboratory, Neurology Service, VA Medical Center, and the Department of Neurology, Baylor College of Medicine, Houston, TX.

Cross-sectional analysis of CBF values was carried out among 668 volunteers and patients. Subjects were subdivided according to age, gender, and degree of cerebrovascular disease, ranging from healthy volunteers with or without risk factors for stroke to patients with multi-infarct dementia. Four-year longitudinal analysis was also carried out on 230 individuals from the original sample, Decrements in CBF values were evidenced by both cross-sectional and longitudinal analysis in relation to advancing age, progressive cerebrovascular disease, and dementia. Regional, age-related CBF declines in healthy volunteers were heterogeneous, possibly related to changes in levels of functional activity within different brain regions.

Address correspondence and reprint requests to Dr. Meyer. Director, Cerebral Blood Flow Laboratory, Neurology Service, VA Medical Center, 2002 Holcombe Blvd., Houston, TX 77211.

This work was supported by the Veterans Administration, Washington, DC, and US Public Health Service Grant NS09287.

Accepted for publication November 4, 1983.




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