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From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
No uniformly accepted hypothesis explains the genesis and rupture of intracranial aneurysms. We followed 5,184 men and women prospectively for 26 years; 36 cases of aneurysmal subarachnoid hemorrhage (SAH) accounted for 62% of all intracranial hemorrhages. Blood pressure before SAH was higher in these patients than in controls. Definite hypertension (2160 mm Hg and/or 295 mm Hg) at entry to the study or at closest exam before SAH was more frequent than in controls. Cigarette smoking, particularly heavy smoking, was also more frequent among cases.
Address correspondence and reprint requests to Dr. Wolf, Department of Neurology, Boston University School of Medicine, 720 Harrison Avenue, Suite P1105, Boston, MA 02118.
Supported in part by grants No. NIH 1PO INS 16367 and NIH lR0l NS 17950 01 with contracts No. NO1 NS 2 2398 and NO1 NS 2320 (Philip A. Wolf, MD, National Institute of Neurological Communicative Disorders and Stroke); and contracts No. NIH NO1 HV 92922 and NIH NO1 HV 52971 (William B. Kannel, MD, National Heart, Lung, and Blood Institute).
Accepted for publication November 4, 1983.
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