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NEUROLOGY 1983;33:580
© 1983 American Academy of Neurology

Brain regional pharmacokinetics of 11-labeled diphenylhydantoin

Positron emission tomography in humans J. C. Baron, D. Roeda, C. Munari, C. Crouzel, J. P. Chodkiewicz and D. Comar

Service Hospitalier Frédéric Joliot, CEA, Département de Biologie (Drs. Baron, Roeda. Crouzel, and Comar), INSERM (Dr. Munari), and the Department of Neurochirurgie, Hôpital Saint Anne (Dr. Chodkiewicz), Paris, France.

We used positron emission tomography to study the regional cerebral pharmacokinetics of llC-labeled diphenylhydantoin (11C-DPH), which was given intravenously to 10 patients (8 intractable partial epileptics and 2 nonepileptics). In the nonaffected hemisphere, 'IC-DPH concentration in gray matter reached equilibrium with blood within 20 minutes but was still rising at 60 minutes in white matter, where equilibrium was too slow to be detected owing to the fast physical decay of W. Brain-blood concentration ratios at 50 minutes were 1.37 and 1.06 in gray and white matter, respectively, similar but less variable than steady-state DPH ratios reported in human brain surgical samples. There was no indication that normal brain regions of medically resistant epileptics bind DPH less effectively than in nonepileptic patients. Brain and blood 11C-DPH concentrations were well correlated, confirming that the latter gives a reliable estimate of the former in unaffected brain regions.

Address correspondence and reprint requests to Dr. Baron, Service Hospitalier Frédéric Joliot. CEA, Departement de Biologie, 91406 Orsay, France.

Accepted for publication September 3, 1982.




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M. Phelps and J. Mazziotta
Positron emission tomography: human brain function and biochemistry
Science, May 17, 1985; 228(4701): 799 - 809.
[Abstract] [PDF]