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NEUROLOGY 1983;33:495
© 1983 American Academy of Neurology

Syndrome of continuous muscle-fiber activity

Increased CSF GABA and effect of dantrolene

Tetsuo Sakai, MD, Shinichi Hosokawa, MD, Hiroshi Shibasaki, MD, Ikuo Goto, MD, Yoshigoro Kuroiwa, MD, Hiroyuki Sonoda, MD and Yoshiyuki Murai, MD

From the Departments of Neurology (Drs. Sakai, Hosokawa, Shibasaki, Goto, and Kuroiwa) and Anesthesiology (Dr. Sonoda), Faculty of Medicine, Kyushu University, Fukuoka; and Department of Neurology (Dr. Murai), University of Occupational and Environmcntal Health, Kitakyushu, Japan.

In a patient with a syndrome of continuous muscle fiber activity, peripheral nerve block completely abolished the EMG discharges. Reduction of spontaneous discharges by epidural block and demonstration of a silent period after the H response suggested that the disorder may originate in the spinal cord or ventral roots, sparing inhibitory influences on the alpha-motoneuron to some extent. GABA (gamma-aminobutyric acid) content in CSF was remarkably increased. Therapeutically, dantrolene sodium was as effective as phenytoin or carbamazepine.

Address correspondence and reprint requests to Dr. Sakai, Department of Neurology, National Akasaka Hospital, 515 Kurakazu, Chikugo-City, Fukuoka 833, Japan.

This study was supported by Grant No. 81–13 from National Center for Nervous, Mental and Muscular Disorders (NCNMMD) of the Ministry of Health and Welfare, Japan.

Accepted for publication July 20, 1982.






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