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Improvement in neuropsychological pedorznance in patients with refractory seizures after intensive diagnostic and therapeutic intervention

From the University of Michigan Medical Center (Drs. Giordani, Sackellares and Berent) Ann Arbor, MI; Veterans Home of California (Dr. Miller) Yountville, CA; Ann Arbor Veterans Administration Medical Center (Dr. Berent), Ann Arbor; University of Virginia Medical Center (Drs. Sutula and Dreifuss) Charlottesville, VA; University of Missouri Medical School (Dr. Seidenberg), Columbia, MO; University of Alabama in Birmingham (Dr. Boll), Birmingham, AL; and The Chicago Medical School (Dr. O'Leary), North Chicago, IL.

Tests of cognitive, perceptual, motor, and memory function were administered to patients with refractory seizures before and after intensive treatment on a specialized epilepsy unit. Improved test performance related to withdrawal of barbiturates and an overall reduction in the number of antiepileptic drugs but not with reduction of seizure frequency.

Address correspondence and reprint requests to Dr. Berent, 116B, Veterans Administration Medical Center, 2215 Fuller Road, Ann Arbor, MI 48105.

This investigation was supported by NINCDS Contract No. 1-NS-5-2329 (S. Berent) and No. 1-NS-5-2327 (T.J. Boll).

Accepted for publication August 2, 1982.

This article has been cited by other articles:

				R. W. Homan, R. G. Paulman, M. D. Devous Sr, P. Walker, L. W. Jennings, and F. J. Bonte Cognitive Function and Regional Cerebral Blood Flow in Partial Seizures Arch Neurol, September 1, 1989; 46(9): 964 - 970. [Abstract] [PDF]