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Retrograde transport in corticospinal neurons after spinal cord transection

From the Neurology Service, Veterans Administration Medical Center, and the Department of Neuroscience, University of California, San Diego, CA.

Complete spinal cord transection at T-6/T-7 in rats caused a decrease in the number of surviving corticospinal neurons. Cell death began 5 and 10 weeks after cord injury. The number of surviving cells decreased progressively for at least 25 weeks after injury. Surviving cells were identified by their ability to transport horseradish peroxidase (HRP) retrograde from a T-1/T-2 insertion site to cortical cell somas. Therapy aimed at promoting corticospinal tract regeneration must be started early after spinal cord injury.

Address correspondence and reprint requests to Dr. Feringa, Chief, Neurology Service (1271, San Diego VA Medical Center, San Diego, CA 92161.

Supported by research funds from the Veterans Administration.

Accepted for publication July 23, 1982.

This article has been cited by other articles:

				P. S. Fishman Retrograde Changes in the Corticospinal Tract of Posttraumatic Paraplegics Arch Neurol, October 1, 1987; 44(10): 1082 - 1084. [Abstract] [PDF]