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NEUROLOGY 1983;33:442
© 1983 American Academy of Neurology

B-cell differentiation in multiple sclerosis and the effect of intravenous ACTH

Anthony Reder, MD and Gary Birnbaum, MD

From the Department of Neurology, University of Minnesota School of Medicine, Minneapolis, MN.

B-cell differentiation was studied in patients with MS and in age- and sex-matched controls, using a pokeweed mitogen (PWMI-stimulated in vitro culture system. Peripheral blood lymphocytes were obtained and separated into T-cell and non-T-cell fractions. Autologous and allogeneic combinations of T cells and B cells were cultured in the presence of pokeweed mitogen for 7 days. Numbers of plaque-forming cells (PFC) were measured at the end of the culture period. T cells from MS patients before and after a 10-day course of adrenocorticotropic hormone (ACTH) were able to cooperate fully in the generation of PWM-generated PFC. B cells from MS patients showed a decreased ability to differentiate into PFC in the presence of either autologous or allogeneic T cells. No significant change in differentiation was observed after a 10-day course of intravenous ACTH. We were thus unable to demonstrate any alteration in T-cell function in MS but were able to demonstrate a decreased ability of MS B cells to differentiate into immunoglobulin-secreting cells. ACTH had no significant effect on these abnormalities.

Address correspondence and reprint requests to Dr. Birnbaum, Box 241, Mayo Building, University of Minnesota School of Medicine, Minneapolis, MN 55455.

Supported by Grant No. RG-1179-B-4 from the National Multiple Sclerosis Society.

Accepted for publication, July 26, 1982.






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