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NEUROLOGY 1983;33:377
© 1983 American Academy of Neurology

Ethylene oxide polyneuropathy

Shigeki Kuzuhara, MD, Ichiro Kanazawa, MD, Takao Nakanishi, MD and Taihei Egashira, MD

Departments of Neurology (Drs. Kuzuhara, Kanazawa, and NakanishiI and Neurological Surgcry (Dr. Egashiral, Institute of Clinical Medicine, the University of Tsukuba, Ibaraki, Japan.

Sensorimotor polyneuropathy developed in two workers who had been exposed to ethylene oxide gas repeatedly for several months. Sural nerve biopsies revealed axonal degeneration with mild changes of the myelin sheath. Unmyelinated fibers were also involved. Muscle biopsies showed typical denervation atrophy. Symptoms improved after exposure to ethylene oxide terminated.

Address correspondence and reprint requests to Dr. Kuzuhara, Department of Neurology, Institute of Clinical Medicine, the University of Tsukuba, Ibaraki 305, Japan.

Accepted for publication July 1, 1982.




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