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NEUROLOGY 1983;33:306
© 1983 American Academy of Neurology

Chronic spinal muscular atrophy and pallidonigral degeneration

Report of a case

Georges T. Serratrice, MD, Maurice Toga, MD and Jean F. Pellissier, MD

Chu de la Timone. Marseille, France.

A 54-year-old woman without family history of neurologic disease developed proximal limb weakness, wasting, and fasciculation associated with histologic and EMG evidence of denervation. An extrapyramidal syndrome was characterized by tremor, akinesia, and rigidity. After 11 years, autopsy showed neuronal loss in the anterior horns of the spinal cord, pallidum, and substantia nigra. This pattern of chronic spinal pallidonigral degeneration has not been reported previously.

Address correspondence and reprint requests to Dr. Serratrice, Chu de la Timone, 1, Chemin de l'armee dAfrique, 13385 Marseille Codex 4, Marseilles. France.

Accepted for publication June 24, 1982.






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