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Effects of 3-OM-dopa on monoarnine metabolism in rat brain

Departments of Research (Drs. Gervas, Muradas, Bazan, and Aguado) and Neurology, (Dr. Yebenes) C. "Ramon y Cajal." Carret. de Colmenar, Km 9.1, Madrid 34, Spain.

we studied the effects of 3-methoxy, 4-hydroxy-phenylalanine (3-OM-dopa) on monoamine turnover, L-3-4-dihydroxy-phenylalanine (L-dopa) reversal of catecholamine depletion induced by a-methyl-paratyrosine (-MT), and the passage of L-dopa across the blood-brain barrier of the rat brain. 3-OM-dopa did not affect monoamine turnover but interfered with restoration of dopamine levels by L-dopa. In addition, systemic 3-OM-dopa decreased brain uptake of ¹⁴C--dopa. High 3-OM-dopa blood levels may interfere with the therapeutic response to L-dopa in parkinsonism.

Address correspondence and reprint requests to Dr. de Yebenes, Department of Neurology, C. "Ramon y Cajal", Carret. de Colmenar, Km 9.1, Madrid 34, Spain.

Accepted for publication, June 30, 1982.