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Postanoxic symptomatic oscillatory myoclonus

University Department of Neurology, Institute of Psychiatry, and King's College Hospital Medical School, Denmark Hill. London, United Kingdom.

Two young patients with a history of birth anoxia and cerebral palsy developed paroxysmal irregularly oscillating muscle jerks at rest and during voluntary movement. Electrophysiologic studies revealed short bursts of alternating activity at 4 to 6 Hz in antagonist muscles. The absence of time-locked EEG discharges suggests a subcortical origin for this unusual form of myoclonus. A comparison is made between this and previously reported conditions with a similar paroxysmal burstlike nature.

Address correspondence and reprint requests to Dr. Obeso, Facultad de Medicina, Universidad de Navarra, Apartado 192, Pamplona, España.

JAO and JCR were supported by the British MRC, and AEL by the Canadian MRC and an HK Detweiler Travel Fellowship.

Accepted for publication June 24, 1982.

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