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NEUROLOGY 1983;33:234
© 1983 American Academy of Neurology

Immune reactions to P2 protein in human inflammatory demyelinative neuropathies

Burton Zweiman, MD, Abdolmohammad Rostami, MD, PhD, Robert P. Lisak, MD, Anne R. Moskovitz, BS and David E. Pleasure, MD

Allergy and Immunology Section, Department of Medicine and the Department of Neurology, University of Pennsylvania School of Medicine. Philadelphia, PA.

The significance of immune reactions against peripheral nervous system antigens in the human inflammatory polyneuropathies is still uncertain. Using a very sensitive assay, we found greatly increased levels of anti-P2 antibodies in sera of animals with experimental allergic neuritis (EAN) but no increases in humans with acute Guillain-Barre syndrome (GBS), chronic relapsing polyneuritis (CRIP), axonal neuropathy, or normals. P2 protein and CNS basic protein did not induce any increased proliferation in lymphocytes of GBS or CRIP patients. We conclude that P2 and BP appear unlikely to be targets for humoral or cellular immune reactivity in GBS or CRIP.

Address correspondence and reprint requests to Dr. Zweiman, University of Pennsylvania, School of Medicine, Room 512, Johnson Pavillion, Philadelphia, PA 19104.

Supported by NIH Grant No. 1 PO1 NS-08075

Accepted for publication June 21, 1982.




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