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Pharrnacokinetics of valproic acid in children

I. Multiple antiepileptic drug therapy

Departrncnts of Pediatric Neurology and Pharmaceutical Services. St. Paul-Ramscy Medical Center, and the Department of Pharmaceuties, College of Pharmacy. and Division of Pediatric Neurology. University of Minnesota, Minneapolis. MN.

We studied the pharmacokinetics of valproic acid (VPA) in 37 children who were taking other antiepileptic drugs. Thirteen children were studied both after initial and while on maintenance valproic acid therapy. Significant differences occurred between initial and maintenance therapy in the mean apparent volume of distribution and in apparent VPA clearance, whereas VPA half-life remained relatively constant. Analysis of data in the 13 children studied on two occasions demonstrated wide intrapatient variability of VPA pharmacokinetics. Children taking VPA together with other antiepileptic medications generally require higher doses of VPA given more frequently.

Address correspondence and reprint requests t.o Dr. Cloyd, Department Of Pharmaceutical Services, St-Paul-Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101.

This study was supported in part by a grant from the Epilepsy Foundation of America and the Medical Education and Research Foundation of St. Paul-Ramsey Medical Center.

Accepted for publication June 24, 1982.

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