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Meige disease

Acute and chronic cholinergic effects

Department of Neurological Sciences, Rush-Presbyterian-St. Lukes Medical Center, Chicago, IL.

We studied central cholinergic systems in 13 patients with idiopathic adult-onset blepharospasm/oromandibular dystonia (Meige syndrome). Six patients studied acutely, and 12 of 13 patients studied chronically, improved after administration of centrally acting anticholinergic agents. These data suggest that Meige syndrome is pharmacologically similar to other dystonic disorders, in which central cholinergic antagonism is more consistently of benefit than manipulation of central dopaminergic systems.

Address correspondence and reprint requests to Dr. Tanner, Department of Neurological Sciences, Rush-Presbyterian-St. Lukes Medical Center. 1725 W. Harrison, Chicago, IL 60612.

This work was supported in part by grants from the United Parkinson Foundation and the Boothroyd Foundation, Chicago, IL.

Presented in part at the thirty-third annual meeting of the American Academy of Neurology, Toronto, Canada, May 1981.

Accepted for publication November 10, 1981.