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Long-term suppression of central serotonergic activity by corticosteroids

A possible model of steroid-responsive myoclonic disorders

Departments of Neurological Sciences and Pharmacology. Rush Presbyterian-St. Lukes Medical Center, Chicago, IL.

Chronic administration of cortisol succinate (12.5 mg per kilogram per day) to guinea pigs suppressed jumping behavior induced by 1–5 hydroxytryptophan and abolished diurnal threshold variations of this behavior. Chronic corticosteroid administration did not alter threshold or diurnal variations of apomorphine-induced stereotypy. These observations suggest that the efficacy of corticosteroids in some human myoclonic movement disorders may be related to central serotonergic inhibition.

Address correspondence and reprint requests to Dr. Nausieda, the Medical College of Wisconsin, Department of Neurology, 9200 West Watertown Plank Road, Milwaukee, WI 53226.

This work was supported by Presbyterian-St. Luke's Basic Sciences Research Grant No. 47831 and grants from United Parkinson Foundation and the Boothroyd Foundation, Chicago, IL.

Accepted for publication November 23, 1981.