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Pallidonigral pigmentation and spheroid formation with multiple striatal lacunar infarcts

From the Departments of Pathology (Drs. Kim, Parisi, and Collins) and Neurology (Dr. Ramachandran), SUNY-Upstate Medical Center, Syracuse, NY.

A 72-year-old hypertensive man had focal seizures and mild memory loss. At autopsy, there were many lacunar infarcts, particularly in the neostriatum. Rust-brown discoloration and spheroid formation within the globus pallidus and pars reticulata of the substantia nigra resembled Hallervorden-Spatz disease, in which more detailed analysis of the striatum may be worthwhile.

Address correspondence and reprint requests to Dr. Kim, Department of Pathology, SUNY-Upstate Medical Center, 766 Irving Avenue, Syracuse, NY 13210.

Accepted for publication August 8, 1980.

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