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From the Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN.
In four patients, sensorimotor polyneuropathy developed during treatment with disulfiram. Each patient began to improve with the cessation of treatment. Clinical, electrophysiologic, and pathologic observations point to a potentially reversible and probably dose-related axonal polyneuropathy.
Address correspondence and reprint requests to Dr. Mokri, Department of Neurology, Mayo Clinic, Rochester, MN 55905.
This investigation was supported in part by a Peripheral Neuropathy Clinical Center Grant (No. NS14304A) from the National Institutes of Health, Public Health Service; by a Center Grant from MDA 12; and by Mayo, Borchard, Upton, and Gallagher Funds.
Accepted for publication August 18, 1980.
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S. N. Nagendra, M. D. Faiman, K. Davis, J.-Y. Wu, X. Newby, and J. V. Schloss Carbamoylation of Brain Glutamate Receptors by a Disulfiram Metabolite J. Biol. Chem., September 26, 1997; 272(39): 24247 - 24251. [Abstract] [Full Text] [PDF] |
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