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NEUROLOGY 1981;31:695
© 1981 American Academy of Neurology

Antioligodendrocyte antibodies in cerebrospinal fluid of multiple sclerosis and other neurologic diseases

Ute Traugott, M.D. and Cedric S. Raine, Ph.D., D.Sc.

From the Departments of Pathology (Neuropathology) and Neuroscience, the Rose F. Kennedy Center for Research in Mental Retardation and Human Development (Dr. Raine), Albert Einstein College of Medicine, Bronx, NY, and the Neurologic Clinic (Dr. Traugott), Vienna, Austria.

Thirty-one concentrated cerebrospinal fluid (CSF) pools—10 multiple sclerosis (MS), and 21 controls with other neurologic diseases—were tested for antibodies against oligodendrocytes by indirect immunofluorescence on frozen brain sections and by complement fiation (CF) against isolated oligodendrocytes. Oligodendrocyte staining was found in 4 of 10 MS and 7 of 21 control CSF specimens. CF was detected in 4 of 10 MS and 3 of 21 controls. Positive results correlated with high a1bumin:IgG ratios. Using F(ab')2 fragments, specific antibodies against oligodendrocytes were detected in both MS and control specimens. In sera from MS and controls, oligodendrocyte staining was found in 16 of 23 MS samples and 11 of 30 controls. CF was present in one MS serum only. Therefore, antioligodendrocyte antibodies in CSF are not specific indicators for multiple sclerosis.

Address correspondence and reprint requests to Dr. Traugott, Department of Pathology (Neuropathology), Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461.

Supported in part by National Multiple Sclerosis Society grant No. RG 1001-C-3 and USPHS grants Nos. NS 08952 and NS 11920.

Accepted for publication September 3, 1980.






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