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NEUROLOGY 1981;31:668
© 1981 American Academy of Neurology

Suppressor cell activity in multiple sclerosis

William C. Wallen, Ph.D., Sidney A. Houff, M.D., Matti Iivanainen, M.D., Vincent P. Calabrese, M.D. and George H. De Vries, M.D.

From the Infectious Diseases Branch (Drs. Wallen, Houff, and Iivanainen), National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD, and the Departments of Biochemistry (Dr. DeVries) and Neurology (Dr. Calabrese), Medical College of Virginia, Virginia Commonwealth University, Richmond, VA.

Patients with multiple sclerosis and matched controls were tested for lymphocyte stimulation response and induction of suppressor cell activity in response to concanavalin A (Con A) and antigens from axolemma or myelin. Of 17 stable patients, 6 failed to have a suppressor cell response activated by one of these brain cell antigens. Among the patients who lacked these suppressor responses, five had lymphocyte stimulation responses to the same antigens. All matched controls except for one had suppressor cell responses to these antigens, and none responded with a positive cellular immune reaction. We found no difference in lymphoproliferative responses to Con A in patients and controls. The level of suppressor cell activity induced by Con A in the stable MS patients varied but did not differ significantly from that of controls.

Address correspondence and reprint requests to Dr. Wallen, Unit on Acute Viral Disease, Infectious Diseases Branch, RP, MNCDS, National Institutes of Health, Building 36, Room 5D-06, Bethesda, MD 20205.

Accepted for publication September 23, 1980.






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