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Electronmicroscopy of COnjunctival biopsy in mannosidosis

Department of Pediatrics, Shiga Medical College, Otsu (Drs. Yamano and Shimada), the Department of Pediatrics, Osaka University School of Medicine, Osaka (Drs. Okada, Yutaka, and Yabuuchi), and the Department of Pediatrics, Fukuoka University School of Medicine, Fukuoka (Drs. Mitsudome and Itsuki).

Electronmicroscopic examination was performed on conjunctival biopsies from two adolescent siblings with mannosidosis. Fitroblasts and kndothelial cells contained membrane-bound vacuoles and vesicles that contained homogeneous osmiophilic globules. These vesicles seem to be pathognomonic of mannosidosis. Plasma cells also contained membrane-bound vacuoles, suggesting inhibition of the immunoglobulin production.

Address correspondence and reprint requests to Dr. Yamano, Department of Pediatrics, Shiga Medical College, Seta, Otsu-shi, Shiga-ken, 520-2 1, Japan.

Part of this work was supported by Grant No. 80-05 from NCNMMD of the Ministry of Health and Welfare, Japan.

Accepted for publication July 29, 1980