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Frontal lobe astrocytoma following radiotherapy for medulloblastoma

Neurological Institute (Drs. Cohen and Kushner), New York, NY, and the Department of Neurosurgery (Dr. Dell), Tuffs-New England Medical Center, Boston, MA.

A young woman had a frontal lobe astrocytoma 14 years after successful treatment of a posterior fossa medulloblastoma by surgery and whole-neuraxis irradiation. The association of these two tumors is rare, and it is unlikely that the second tumor was the result of metastasis and differentiation of residual or recurrent medulloblastoma. We review the evidence supporting this view and also the likelihood that the astrocytoma was induced by the prior radiation.

Address correspondence and reprint requests to Dr. Kushner, Box 136, the Neurological Institute, 710 West 168th Street, New York, NY 10032.

Accepted for publication July 30, 1980

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