HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mazziotta, J. C. Articles by Kuhl, D. E. Search for Related Content PubMed PubMed Citation Articles by Mazziotta, J. C. Articles by Kuhl, D. E.

Tomographic mapping of human cerebral metabolism

Normal unstimulated state

Department of Neurology (Dr. Mazziotta) and the Division of Nuclear Medicine (Drs. Phelps and Kuhl and Ms. Miller), UCLA School of Medicine and Laboratory of Nuclear Medicine and Radiation Biology, Los Angeles, CA.

Positron computed tomography (PCT) and F-18 2-fluorodeoxyglucose (FDG) were used to study the living human brain in coronal and transverse sections. Scans taken at 1-cm intervals in both directions clearly delineated the cerebral substructures (e.g., cortical areas, basal ganglia, internal capsule, and cerebellum). A compartmental model was used to calculate local cerebral metabolic rates for glucose from the images. Values agreed well with previous global and local human values and demonstrated metabolic symmetry of the left and right hemispheres at rest. Baseline anatomic maps such as these are a necessary prelude to the study of human brain metabolism in stimulated and pathologic states.

Address correspondence and reprint requests to Dr. Mazziotta, Department of Neurology, Reed Neurologic Institute, UCLA School of Medicine, Los Angeles, CA 90024.

This work was partially supported by DOE contract DE-AM03-76-SF00012, and NIH grants ROI-GM-24839-01 and POI-NS-15654-01

Presented at the thirty-second annual meeting of the American Academy of Neurology, New Orleans, LA, May 2, 1980.

Accepted for publication November 5, 1980.

This article has been cited by other articles:

				W.-D. Heiss, B. Habedank, J. C. Klein, K. Herholz, K. Wienhard, M. Lenox, and R. Nutt Metabolic Rates in Small Brain Nuclei Determined by High-Resolution PET J. Nucl. Med., November 1, 2004; 45(11): 1811 - 1815. [Abstract] [Full Text] [PDF]

				T. Postert, A. Muhs, S. Meves, J. Federlein, H. Przuntek, and T. Buttner Transient Response Harmonic Imaging : An Ultrasound Technique Related to Brain Perfusion Stroke, September 1, 1998; 29(9): 1901 - 1907. [Abstract] [Full Text] [PDF]

				H. Kuchiwaki, S. Inao, K. Yoshida, and K. Sugita Effect of Intracarotid Administration of 6-Aminonicotinamide on Cerebral Blood Flow in Cats Stroke, March 1, 1995; 26(3): 473 - 479. [Abstract] [Full Text]

				J. M. Hoffman, J. C. Mazziotta, T. C. Hawk, and R. Sumida Cerebral Glucose Utilization in Motor Neuron Disease Arch Neurol, August 1, 1992; 49(8): 849 - 854. [Abstract] [PDF]

				H. Chugani and M. Phelps Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography Science, February 21, 1986; 231(4740): 840 - 843. [Abstract] [PDF]

				M. S. Buchsbaum, D. H. Ingvar, R. Kessler, R. N. Waters, J. Cappelletti, D. P. van Kammen, A. C. King, J. L. Johnson, R. G. Manning, R. W. Flynn, et al. Cerebral Glucography With Positron Tomography: Use in Normal Subjects and in Patients With Schizophrenia Arch Gen Psychiatry, March 1, 1982; 39(3): 251 - 259. [Abstract] [PDF]