HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Longstreth, W. T. Articles by Sumi, S. M. Search for Related Content PubMed PubMed Citation Articles by Longstreth, W. T., Jr., M.D. Articles by Sumi, S. M.

Cerebrospinal fluid and Serum creatine kinase BB activity after out-of-hospital cardiac arrest

From the Division of Neurology (Drs. Longstreth and Sumi) Department of Medicine, Harborview Medical Center, and the Department of Laboratory Medicine (Ms. Clayson). University of Washington School of Medicine, Seattle, WA.

Address correspondence and reprint requests to Dr. Sumi, Division of Neurology, Harborview Medical Center, 325 Ninth Avenue. Seattle, WA 98104.

In patients resuscitated from out-of-hospital cardiac arrest, neurologic outcome was compared with creatine kinase isoen-zyme BB activity (CKBB) in cerebrospinal fluid (CSF) in 20 patients and in serum in 52 patients. CSF CKBB was 2 units Der liter or less in patients with complete neurologic recovery but was significantly elevated in patients without neurologic recovery (mean, 55 units per liter) or with incomplete neurologic recovery (mean, 7 units per liter). Serum CKBB was detected more than 6 hours after cardiac arrest in only 4% of patients with complete neurologic recovery but in all patients without neurologic recovery. These results demonstrate a relationship between CSF and serum CKBB and neurologic outcome after cardiac arrest.

Accepted for publication June 25. 1980