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Marchiafava- Bignami disease

Neurology Service, Veterans Administration Hospital, and the Department of Neurology, Albany Medical College, Albany, New York.

Marchiafava-Bignami disease was diagnosed postmortem in a 39-year-old man who drank excessive amounts of white port wine. This is the fifth report of the disease in a native North American with no Italian ancestry. The lesion involved the corpus callosum and hippocampal commissure but spared the anterior commissure, middle cerebellar peduncles, optic chiasm, and centrum semiovale. Wernicke-Korsakoff encephalopathy and pellagroid neuronal changes were also present.

Reprint requests should be addressed to Dr. Koeppen. Neurology Service, VA Hospital, Albany, NY 12208.

This paper was originally accepted for publication in November 1976. Its publication has been delayed due to relocation of editorial offices.

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