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Neurologic manifestations of Cogan syndrome

Neurology Service, Veterans Administration Hospital, Albuquerque, and the Department of Neurology, University of New Mexico School of Medicine, Albuquerque, New Mexico.

Cogan syndrome is a multisystem inflammatory vascular disease, characterized by nonsyphilitic interstitial keratitis and vestibuloauditory symptoms. Recent reports have directed attention to involvement of other organ systems. Respiratory, cardiovascular, gastrointestinal, and musculoskeletal problems are common, as are laboratory abnormalities and general symptoms such as fever, chills, and weight loss. Prominent neurologic problems in two patients prompted a review of 79 cases of Cogan syndrome. More than half had nervous system involvement, including electroencephalographic or spinal fluid abnormality, headache, psychosis, coma, convulsion, neuropathy, and stroke. Cogan syndrome should be considered when neurologic deficits are accompanied by eye, ear, and systemic symptoms.

Requests for reprints should be addressed to Dr. Bicknell, Neurology Service, Veterans Administration Hospital, Albuquerque, NM 87108.

Accepted for publication April 25, 1977.

This article has been cited by other articles:

				M. S. Albayram, R. Wityk, D. M. Yousem, and S. J. Zinreich The Cerebral Angiographic Findings in Cogan Syndrome AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 751 - 754. [Abstract] [Full Text]