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Recent cases of intracranial tuberculomas

Departments of Pediatrics, Neurology, and Medicine, Division of Infectious Disease, Montefiore Hospital and Medical Center and Albert Einstein College of Medicine, Bronx, New York.

While intracranial tuberculomas have become uncommon in industrial nations, 12 patients with signs and symptoms of an intracranial mass lesion were recently found to have tuberculomas. Clinical findings suggestive of tuberculosis were frequently subtle or absent. Five patients did not have extracranial tuberculosis. Two patients had intracranial tuberculomas that became superinfected with bacteria and appeared initially as pyogenic brain abscesses. Intracranial tuberculomas in this country almost always occur in adults and represent reactivation of dormant infection. Medical therapy alone is indicated as the initial therapy except in the presence of intolerably increased intracranial pressure. A chemotherapeutic regimen is suggested.

Reprint requests should be addressed to Dr. Kaufman, Department of Neurology, Montefiore Hospital and Medical Center, 111 East 210th Street, Bronx, NY 10467.

Support for this study was provided by United States Public Health Service Training Grant TO1 Al 00405-05 from the National Institute of Allergy and Infectious Diseases.

Accepted for publication June 2, 1977.

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