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Cranial CT appearance of acute multiple sclerosis

Department of Neurology, University of Nebraska Medical Center (Drs. Aita and Bennett); Department of Radiology, University of Utah Medical Center (Dr. Anderson); and Department of Neurology, University of Utah Medical Center (Dr. Ziter).

In acute multiple sclerosis, cranial computerized tomography (CT) may show periventricular and deep white matter contrast-enhanced lesions that are easier to see using 8 mm rather than 13 mm cranial CT sections. Follow-up studies show that the lesions evolve either to areas of density similar to the surrounding white matter or to low-density lesions. We presume they represent foci of active demyelination with extravasation of iodine through an altered blood-brain barrier. Enhanced cranial CT studies may be helpful in diagnosing acute multiple sclerosis and in following the course of the white matter lesions.

Reprint requests should be addressed to Dr. Aita, Department of Neurology, University of Nebraska Medical Center, 42nd and Dewey, Omaha, NE 68105.

Dr. Aita's address is Midwest Clinic, 105 S. 49th Street, Omaha, Nebraska 68132.

Accepted for publication June 24, 1977.

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