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Division of Clinical Electrophysiology, Department of Neurology, University of Iowa Hospitals, Iowa City, Iowa.
Somatosensory evoked potentials (SEPs) elicited by bilaterally simultaneous median nerve stimulation (BS) were studied in 28 normal subjects and in 20 patients with various cerebral lesions. In normals, SEPs evoked by BS were symmetric between the homologous areas of the two hemispheres and resembled the response contralateral to unilateral stimulation (US). In patients with a cerebral lesion, BS responses were not only asymmetric but often differed in wave form from the response of the affected hemisphere to contralateral US. These alterations were attributed to the cumulative interactions of the anomalous contralateral and ipsilateral components. The additional use of BS made it possible to demonstrate SEP abnormalities that might have been regarded as normal or equivocal if only the US method had been used. The neurophysiologic mechanisms of the origin of SEP are discussed.
Address reprint requests to Dr. Yarnada, Director, EEG Laboratory University of Iowa Hospitals, Iowa City, IA 52242.
Presented in part at the 1976 annual meeting of the American Electroencephalographic Society, Detroit, October 1976.
This study was supported in part by a grant from the University of Iowa research fund.
Accepted for publication May 2, 1977.
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