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Platelet aggregation, stroke, and transient ischemic attack in middle-aged and elderly patients

From the Departments of Neurology (Dr. Couch) and Biometry (Dr. Hassanein), University of Kansas Medical Center, 39th Rainbow Boulevard, Kansas City, Kansas.

Platelet aggregation was studied with optical density methods in a group of 39 patients with stroke or transient ischemic attacks (TIA) and in age, sex, and race-matched controls. The patients were divided at age 60 into young stroke patients and young controls (18 pairs) and old stroke patients and old controls (21 pairs). A semiquantitative measure of the threshold of phase II of platelet aggregation and extent of disaggregation 3 minutes after peak aggregation were used as an index of platelet aggregability. Aggregability was significantly greater in young stroke patients than in young controls. Aggregability was similar in old stroke patients and old controls. Both old stroke patients and old controls were hyperaggregable compared with young controls, indicating that aggregability rises with age. This suggests that platelet aggregability is a significant risk factor for stroke but is relatively more important in the younger than in the older stroke patient.

Dr. Couch's address is Department of Neurology, University of Kansas Medical Center, Rainbow Blvd. at 39th St., Kansas City, KS 66103.

This study was supported in part by a grant from Marion Laboratories, Kansas City, Missouri, and by grant No. 1 R01 NS10704 01A1. National Institute of Neurological Disease and Stroke, National Institutes of Health. Also supported in part by a grant (RR-828) from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health.

Presented at the twenty-seventh annual meeting of the American Academy of Neurology, Bal Harbour, Florida, May 1975.

Received for publication November 14, 1975.

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