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Quantitative histochemical evaluation of normal human skeletal muscle

From the Department of Psychiatry, University of Chicago Pritzker School of Medicine, Chicago.

Skeletal muscle tissue was obtained by open biopsy from the vastus lateralis and peroneus brevis muscles from 12 and 16 healthy paid volunteers, respectively. Frozen sections were examined with standard histochemical methods. Central nuclei, small and large angular fibers, and small round fibers were the most common "abnormalities" present. The number of fibers of these types were quantified, along with other more rare deviations from normal morphology. Several of the abnormalities were more common in the peroneus brevis than in the vastus lateralis.

Dr. Meltzer's address is Department of Psychiatry, University of Chicago, 950 E. 59th St., Chicago, IL 60637.

This study was supported by USPHS grant No. 18396 and by grant No. 431-RD from the Department of Mental Health of the State of Illinois.

Received for publication August 5, 1975.