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NEUROLOGY 1976;26:839
© 1976 American Academy of Neurology

Recovery in rats after spinal cord injury

EARL R. FERINGA, M.D., WAYNE K. KINNING, M.D., ALAN G. BRITTEN, M.S. and H. LEE VAHLSING, M.S.

From the Departments of Neurology and Pathology, Ann Arbor Veterans Administration Hospital and the University of Michigan Medical Center, Ann Arbor.

Previous studies from this laboratory have shown evidence of regeneration of long descending spinal motor tracts in rats after spinal cord transection and treatment to modify the animals' immune response. In this study, less extensive surgical lesions were combined with the most favorable drug treatment (75 mg per kilogram of cyclophosphamide in a single dose) in an effort to improve the prospects for regeneration. Less than complete spinal cord transections in the rat were frequently followed by clinical and electrophysiologic evidence of return of function. Such return of function appears to depend on a reorganization of the nervous system that results in the use of the few remaining fibers to transmit motor information rather than on regeneration. Immunosuppressive treatment had no effect on these results.

Requests for reprints should be addressed to Dr. Feringa, Department of Neurology (180), Veterans Administration Hospital, 2215 Fuller Road, Ann Arbor, MI 48105.

This study was supported by the Veterans Administration Hospital, Ann Arbor, Michigan.

Received for publication September 4, 1975.




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