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NEUROLOGY 1976;26:785
© 1976 American Academy of Neurology

Brain serotonin after experimental vascular occlusion

BOGOMIR B. MRSULJA, M.D., Ph.D., BRANISLAVA J. MRSSULJA, M.D., MARIA SPATZ, M.D. and IGOR KLATZO, M.D.

From the Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, and Laboratory for Neurochemistry, Institute of Biochemistry, School of Medicine, Belgrade, Yugoslavia (Dr. Mrsulja).

Unilateral ligation of a common carotid artery in gerbils causes a decreased rate of serotonin synthesis and degradation but an increased release of this monoamine. In the brain, reduction of cerebral serotonin content during ischemia is followed by accumulation of its main metabolite, 5-hydroxyindolacetic acid. These data support the contention that serotonin plays an important role in the progression of cerebral infarction.

Dr. Mrsulja's address is Institute of Biochemistry, School of Medicine, Belgrade, Yugoslavia.

Received for publication August 11,1975.




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